The Effect of Brown Rice on Superoxide Dismutase Level and Non-alcoholic Fatty Liver in an Sprague–Dawley Rat Model of Highfat High-fructose Diet-induced Obesit

Kumpulan	: Jurnal Ilmiah (Non-Kategori) [Inggris]
Edisi/Volume	: ,
Pengarang	: Inggita Kusumastuty , Dian Handayani , Shafira Hanifa , Melinda Lisan , Etik Sulistyowati
Klasifikasi/Subjek	: ,
Penerbitan	: Poltekkes Malang, Malang: 2020.
Bahasa	: Inggris
PENYIMPANAN
Lokasi	: PUSAT-30-A-
Jumlah	: 1

Abstraksi

BACKGROUND: Obesity can cause oxidative stress due to the release of free radical components or reactive oxygen species. The accumulation of excess fat in obesity also causes the occurrence of non-alcoholic fatty liver. Brown rice is a functional food with higher fiber, vitamin, mineral, and antioxidant contents than those in white rice. AIM: This study was aimed to evaluate the effect of brown rice on the superoxide dismutase (SOD) level and nonalcoholic fatty liver in obese Sprague–Dawley rats. METHODS: An experimental study using a post-test-only control group design was carried out on a Sprague– Dawley rat model of obesity-induced by a high-fat high fructose (HFHF) diet. Sample selection was done through simple random sampling; rats were divided into five groups, namely the normal diet group (K−), the HFHF diet group (K+), and HFHF diet groups with the addition of brown rice dose I (P1), dose II (P2), and dose III (P3). The measured variable was the SOD level measured using the spectrophotometric method and the calculation of the percentage of fatty liver cells on the results of a hematoxylin-eosin liver scan of a rat’s right lobe. RESULTS: The dose of brown rice was not affected body weight of the rats significantly compared to the control groups. Then, there were significant differences in the SOD level and fatty liver in at least two groups (p = 0.01 and p = 0.001). CONCLUSION: This study concludes that the administration of brown rice contributes to the increasing SOD level and decreasing fatty liver in obese model rats

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